Bedrock Guardrails Implementation for PHI / PII - Healthcare / FS / LS

Bedrock Guardrails out-of-box is not tuned for PHI / PII / NPI. Healthcare, life sciences, and financial services need industry-specific denied-topics taxonomies, custom PHI / PII blocklists, fairness filters, and jailbreak / prompt-injection defenses before production launch. Until now, no fixed-fee regulated-industry Bedrock Guardrails implementation SKU has existed on AWS Marketplace.

Amazon Bedrock Guardrails is the policy-enforcement layer around Claude-powered agents operating on PHI, PII, NPI (GLBA), cardholder data (PCI DSS), and protected-class attributes. Guardrails ships with generic denied topics, content filters, PII redaction, word filters, and contextual grounding, but none are tuned for regulated-industry contexts. Healthcare needs medical-misinformation filters, self-diagnosis guardrails, unprescribed-medication denial, PHI-disclosure-prompt detection. Life sciences needs unapproved-indication filters, GxP deviation denial, adverse-event handling, controlled-substance advice blocks. Financial services needs unlicensed-investment-advice filters, fair-lending / disparate-impact detection, OFAC / PEP sanctions-adjacency, market-manipulation / insider-trading denial. All three need jailbreak + prompt-injection + indirect-PI defenses (OWASP Top 10 for LLM 2024/2025) tuned against adversarial corpora, not generic thresholds.

Existing AWS Marketplace listings don't close this gap. EnviroWay Advisory is generalist; AIM Consulting is assessment-only; DevIQ HIPAA Bedrock Review is architecture review; TCS 5A Framework is methodology; Data Reply / Altimetrik / CrowdStrike AI Red Team are offensive testing, not defensive deployment. Off-Marketplace consulting (Slalom, Caylent, Rackspace, Deloitte) $75K–$250K custom-priced. Content-safety SaaS (Lakera Guard, Protect AI, Arthur AI) are $50K–$300K/yr subscriptions.

Bedrock Guardrails configured + tuned. Denied topics, Healthcare (medical misinformation, self-diagnosis, unprescribed-medication, PHI-disclosure prompts); Life sciences (unapproved indications, GxP deviations, adverse-event mishandling, controlled-substance advice); FS (unlicensed investment advice, fair-lending violations, OFAC/PEP, market manipulation, insider trading). Content filters tuned per industry. PII redaction (built-in + custom regex for SSN, MRN, policy/account numbers, credit cards). Word filters (clinical terminology, controlled vocabulary). Contextual grounding (RAG + relevance thresholds calibrated against test corpus). Sensitive-info filters (Comprehend Medical PHI entities; Macie PII at rest). Custom fairness filters (disparate-impact + proxy scanning). Jailbreak + PI defenses (input validation, output sanitization, indirect-PI scanning, tool-poisoning for MCP-wired agents). A/B testing harness (precision / recall / F1 / FPR). Red-team corpus (Enterprise), OWASP Top 10 for LLM.

Reference architecture. Guardrails per-agent around Bedrock Agents, Claude Agent SDK, MCP servers. Comprehend Medical for PHI; Macie for PII at rest. CloudTrail + Bedrock Model Invocation Logging capture every trigger + override. CloudWatch + QuickSight dashboards.

Week-by-week. W1 Scoping + baseline. W2 Denied topics + PII redaction (5/15/30 topics per tier). W3 Content filters + Comprehend Medical + Macie + contextual grounding + integration, Foundation closes. W4 Standard, jailbreak + PI tuning; fairness; A/B testing (45-day warranty). W5 Enterprise, custom PHI/PII blocklists; full fairness; red-team; SOC 2 + HIPAA + NIST AI RMF evidence (60-day hypercare).

Three tiers. Foundation $35K (3 wk; 1 industry; 5 denied-topics; 1 agent; 30-day warranty) for mid-sized regulated with single customer-facing agent. Standard $65K (4 wk; 2 industries; 15 denied-topics; jailbreak + PI tuning; fairness; A/B testing; SOC 2 evidence; 45-day warranty) for multi-agent / multi-industry. Enterprise $95K (5 wk; all 3 industries; 30 denied-topics; custom PHI/PII blocklists, ICD-10, drug names, sanctions lists, fair-lending proxies; full fairness; OWASP Top 10 red-team; full SOC 2 + HIPAA + NIST AI RMF evidence; 60-day hypercare) for large regulated, G-SIB banks, top-25 payers + pharmas. Optional Extra Denied-Topic Suite $15K each.

Important disclosures. Kriv does NOT develop Customer agents, Guardrails tune surrounding controls only. Does NOT operate Guardrails post-deployment (unless Managed Service retainer). Issues no SOC 2 / HIPAA / HITRUST / ISO certifications. No legal / regulatory / compliance advice. No 100% jailbreak / PI prevention guarantee, defense-in-depth, not absolute. No Bedrock Guardrails API stability guarantee. AWS + Anthropic + Bedrock + Guardrails per-text-unit consumption separate. Red-team scoped Enterprise only. No false-positive elimination guarantee. No HHS OCR / FTC / state-regulator outcome guarantee. Anthropic CPN membership does not constitute endorsement.